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PH and SICH but not HI were associated with rtPA. Also, PH and SICH but no HI were more severe in rtPA-treated patients than in those receiving placebo. Risk factors for PH were rtPA, extent of parenchymal hypoattenuation on baseline CT, c ongestive heart failure, increasing age, and baseline systolic blood pressure. The risk of PH on rtPA was increased in older patients and in those who were treated with aspirin before thrombolysis. Risk factors for SICH were rtPA, congestive heart failu re, extent of parenchymal hypoattenuation, and increasing age. The risk of SICH on rtPA was increased in patients who were treated with aspirin before thrombolysis. This secondary analysis of ECASS II has confirmed the importance of the extent of hypoat tenuation as a risk factor for severe HT. The findings also suggest that older patients and those who have used aspirin before stroke are at a higher risk of a severe HT on rtPA. |
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adverse drug reaction
aspirin
CAT scan
CAT scan,abnormal
cerebral infarction,hemorrhagic
cerebrovascular accident,thrombolytic agents in treatment
fibrinolytic agents
fibrinolytic agents,complications
intracerebral hemorrhage
old age,neurology of
risk factors
tissue plasminogen activator,intravenous
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